Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
v2r_human 21 N-term S => Ter stop gained 1.152e-05 1 86826 0 None None
v2r_human 354 C-term Q => Ter stop gained 3.492e-05 3 85913 0 None None
v2r_human 7 N-term T => S missense 0.009278 814 87737 21 0.08 0.024
v2r_human 9 N-term A => T missense 1.14e-05 1 87737 0 0.12 0.207
v2r_human 12 N-term G => E missense 0.04551 1575 34609 40 0.01 0.095
v2r_human 27 N-term R => G missense 4.579e-05 2 43673 0 0.31 0.001
v2r_human 34 1.29x29 TM1 P => L missense 5.685e-05 3 52773 0 0.15 0.003
v2r_human 38 1.33x33 TM1 R => W missense 5.08e-05 3 59060 0 0.01 0.888
v2r_human 38 1.33x33 TM1 R => Q missense 3.335e-05 2 59971 0 0.4 0.01
v2r_human 42 1.37x37 TM1 A => V missense 0.003833 258 67306 4 0.04 0.701
v2r_human 46 1.41x41 TM1 I => M missense 1.352e-05 1 73966 0 0.05 0.17
v2r_human 56 1.51x51 TM1 G => S missense 1.268e-05 1 78880 0 0.52 0.02
v2r_human 58 1.53x53 TM1 V => A missense 1.258e-05 1 79510 0 0.0 0.997
v2r_human 60 1.55x55 TM1 A => V missense 1.252e-05 1 79892 0 0.38 0.326
v2r_human 62 1.57x57 TM1 L => V missense 1.241e-05 1 80594 0 0.0 1.0
v2r_human 64 1.59x59 TM1 R => W missense 0.0001604 12 74808 0 0.0 0.999
v2r_human 66 1.61x61 TM1 G => S missense 1.245e-05 1 80292 0 0.07 0.444
v2r_human 67 1.62x62 TM1 R => W missense 1.235e-05 1 80987 0 0.0 0.959
v2r_human 68 1.63x63 TM1 R => Q missense 0.001164 93 79889 0 0.05 0.627
v2r_human 76 2.41x41 TM2 V => I missense 1.186e-05 1 84317 0 0.06 0.053
v2r_human 79 2.44x44 TM2 G => A missense 4.711e-05 4 84902 0 0.17 0.141
v2r_human 104 23.49x49 ECL1 R => H missense 9.27e-05 8 86304 0 0.01 1.0 LB (polar (charge-assisted hydrogen bond))
v2r_human 106 23.51x51 ECL1 R => H missense 0.0009726 84 86367 0 0.46 0.013
v2r_human 114 3.27x27 TM3 A => T missense 2.308e-05 2 86657 0 0.17 0.803
v2r_human 115 3.28x28 TM3 V => M missense 2.308e-05 2 86667 0 0.0 0.997
v2r_human 123 3.36x36 TM3 M => T missense 1.152e-05 1 86781 0 0.0 1.0 LB (hydrophobic, Van der Waals)
v2r_human 128 3.41x41 TM3 Y => F missense 9.217e-05 8 86793 1 0.01 1.0
v2r_human 129 3.42x42 TM3 M => V missense 1.152e-05 1 86794 0 0.03 0.759
v2r_human 134 3.47x47 TM3 T => M missense 1.152e-05 1 86792 0 0.0 1.0
v2r_human 137 3.50x50 TM3 R => C missense 1.152e-05 1 86794 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
v2r_human 139 3.52x52 TM3 R => H missense 0.0005875 51 86813 0 0.16 0.36
v2r_human 143 3.56x56 TM3 R => H missense 2.304e-05 2 86806 0 0.55 0.059 GP (contact)
v2r_human 143 3.56x56 TM3 R => L missense 1.152e-05 1 86806 0 0.24 0.881 GP (contact)
v2r_human 144 34.50x50 ICL2 P => A missense 2.304e-05 2 86820 0 0.0 1.0 GP (contact)
v2r_human 147 34.53x53 ICL2 A => V missense 0.006035 524 86824 13 0.03 0.564 GP (contact)
v2r_human 151 34.57x57 ICL2 G => R missense 1.152e-05 1 86818 0 0.08 0.949 GP (contact)
v2r_human 153 4.39x39 TM4 G => E missense 6.912e-05 6 86810 0 0.69 0.864
v2r_human 158 4.44x44 TM4 R => Q missense 0.0001383 12 86758 0 0.29 0.06
v2r_human 159 4.45x45 TM4 P => S missense 1.153e-05 1 86737 0 0.02 0.732
v2r_human 162 4.48x48 TM4 V => A missense 6.941e-05 6 86443 0 0.37 0.023
v2r_human 163 4.49x49 TM4 A => S missense 2.315e-05 2 86407 0 0.07 0.994
v2r_human 170 4.56x56 TM4 L => V missense 1.162e-05 1 86092 0 0.03 0.904
v2r_human 199 ECL2 P => S missense 1.144e-05 1 87438 0 0.08 1.0
v2r_human 202 5.35x36 TM5 R => C missense 1.143e-05 1 87488 0 0.02 0.735 LB (polar (charge-assisted hydrogen bond))
v2r_human 215 5.48x48 TM5 V => M missense 0.0004794 42 87617 1 0.0 0.981
v2r_human 223 5.56x56 TM5 A => T missense 0.0004907 43 87621 0 0.24 0.172
v2r_human 230 5.63x63 TM5 R => Q missense 4.566e-05 4 87606 0 0.01 0.989
v2r_human 233 5.66x66 TM5 H => R missense 1.141e-05 1 87615 0 0.13 0.988 GP (contact)
v2r_human 244 ICL3 P => T missense 1.142e-05 1 87528 0 0.56 0.006
v2r_human 245 ICL3 G => A missense 6.858e-05 6 87489 0 0.25 0.227
v2r_human 247 ICL3 R => C missense 1.147e-05 1 87188 0 0.08 0.013
v2r_human 247 ICL3 R => H missense 0.0008372 73 87199 0 0.14 0.022
v2r_human 248 ICL3 R => C missense 9.175e-05 8 87191 0 0.05 0.048
v2r_human 248 ICL3 R => H missense 4.588e-05 4 87187 0 0.15 0.048
v2r_human 250 ICL3 G => E missense 0.000298 26 87242 0 0.11 0.069
v2r_human 251 ICL3 R => G missense 0.0002981 26 87211 0 0.4 0.015
v2r_human 251 ICL3 R => C missense 1.147e-05 1 87211 0 0.08 0.009
v2r_human 251 ICL3 R => H missense 3.428e-05 3 87511 0 0.18 0.009
v2r_human 252 ICL3 R => W missense 0.002446 214 87502 2 0.03 0.022
v2r_human 252 ICL3 R => Q missense 4.572e-05 4 87493 0 0.31 0.041
v2r_human 257 ICL3 G => S missense 4.569e-05 4 87537 0 1.0 0.002
v2r_human 265 6.29x29 TM6 A => V missense 1.141e-05 1 87633 0 0.0 0.994 GP (contact)
v2r_human 266 6.30x30 TM6 V => L missense 1.141e-05 1 87641 0 0.12 0.019 SodiumPocket MicroSwitch
v2r_human 266 6.30x30 TM6 V => A missense 0.0001597 14 87638 0 0.03 0.297 SodiumPocket MicroSwitch
v2r_human 268 6.32x32 TM6 K => R missense 1.141e-05 1 87654 0 0.05 0.999 GP (contact)
v2r_human 270 6.34x34 TM6 V => G missense 1.141e-05 1 87656 0 0.0 0.943 SodiumPocket MicroSwitch
v2r_human 270 6.34x34 TM6 V => A missense 1.141e-05 1 87656 0 0.03 0.381 SodiumPocket MicroSwitch
v2r_human 279 6.43x43 TM6 V => I missense 4.565e-05 4 87628 0 0.12 0.786
v2r_human 295 6.59x59 TM6 A => S missense 1.16e-05 1 86211 0 0.01 0.955 LB (Van der Waals, polar (hydrogen bond with backbone))
v2r_human 295 6.59x59 TM6 A => V missense 1.161e-05 1 86106 0 0.83 0.035 LB (Van der Waals, polar (hydrogen bond with backbone))
v2r_human 298 ECL3 P => L missense 2.333e-05 2 85740 0 0.01 0.916
v2r_human 300 ECL3 A => P missense 1.169e-05 1 85550 0 0.24 0.991
v2r_human 305 7.33x32 TM7 A => T missense 0.0002373 20 84299 0 0.17 0.003
v2r_human 305 7.33x32 TM7 A => V missense 8.305e-05 7 84291 0 0.01 0.731
v2r_human 306 7.34x33 TM7 P => S missense 1.186e-05 1 84348 0 0.07 0.431
v2r_human 310 7.38x37 TM7 L => F missense 2.37e-05 2 84403 0 0.0 0.987
v2r_human 337 8.55x55 H8 R => Q missense 5.93e-05 5 84310 0 nan 0.961
v2r_human 340 8.58x58 H8 L => F missense 4.736e-05 4 84465 0 0.13 0.015
v2r_human 344 8.62x62 H8 R => G missense 2.358e-05 2 84829 0 0.26 0.024
v2r_human 344 8.62x62 H8 R => Q missense 5.885e-05 5 84959 0 nan 0.003
v2r_human 346 C-term R => C missense 4.7e-05 4 85107 0 0.01 0.003
v2r_human 349 C-term P => L missense 1.167e-05 1 85661 0 nan 0.075
v2r_human 352 C-term G => R missense 2.328e-05 2 85898 0 nan 0.897
v2r_human 352 C-term G => D missense 0.0006866 59 85930 0 0.38 0.142
v2r_human 357 C-term S => P missense 1.165e-05 1 85841 0 0.01 0.883
v2r_human 357 C-term S => F missense 4.671e-05 4 85642 0 0.0 0.862
v2r_human 359 C-term T => I missense 1.172e-05 1 85331 0 nan 0.862
v2r_human 359 C-term T => N missense 1.172e-05 1 85331 0 nan 0.912
v2r_human 368 C-term D => G missense 1.263e-05 1 79158 0 0.01 0.619
v2r_human 371 C-term S => L missense 1.35e-05 1 74056 0 nan 0.336


Residue

Diagrams

ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
SnakePlot Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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