Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
v2r_human | 21 | N-term | S => Ter | stop gained | 1.152e-05 | 1 | 86826 | 0 | None | None | ||
v2r_human | 354 | C-term | Q => Ter | stop gained | 3.492e-05 | 3 | 85913 | 0 | None | None | ||
v2r_human | 7 | N-term | T => S | missense | 0.009278 | 814 | 87737 | 21 | 0.08 | 0.024 | ||
v2r_human | 9 | N-term | A => T | missense | 1.14e-05 | 1 | 87737 | 0 | 0.12 | 0.207 | ||
v2r_human | 12 | N-term | G => E | missense | 0.04551 | 1575 | 34609 | 40 | 0.01 | 0.095 | ||
v2r_human | 27 | N-term | R => G | missense | 4.579e-05 | 2 | 43673 | 0 | 0.31 | 0.001 | ||
v2r_human | 34 | 1.29x29 | TM1 | P => L | missense | 5.685e-05 | 3 | 52773 | 0 | 0.15 | 0.003 | |
v2r_human | 38 | 1.33x33 | TM1 | R => W | missense | 5.08e-05 | 3 | 59060 | 0 | 0.01 | 0.888 | |
v2r_human | 38 | 1.33x33 | TM1 | R => Q | missense | 3.335e-05 | 2 | 59971 | 0 | 0.4 | 0.01 | |
v2r_human | 42 | 1.37x37 | TM1 | A => V | missense | 0.003833 | 258 | 67306 | 4 | 0.04 | 0.701 | |
v2r_human | 46 | 1.41x41 | TM1 | I => M | missense | 1.352e-05 | 1 | 73966 | 0 | 0.05 | 0.17 | |
v2r_human | 56 | 1.51x51 | TM1 | G => S | missense | 1.268e-05 | 1 | 78880 | 0 | 0.52 | 0.02 | |
v2r_human | 58 | 1.53x53 | TM1 | V => A | missense | 1.258e-05 | 1 | 79510 | 0 | 0.0 | 0.997 | |
v2r_human | 60 | 1.55x55 | TM1 | A => V | missense | 1.252e-05 | 1 | 79892 | 0 | 0.38 | 0.326 | |
v2r_human | 62 | 1.57x57 | TM1 | L => V | missense | 1.241e-05 | 1 | 80594 | 0 | 0.0 | 1.0 | |
v2r_human | 64 | 1.59x59 | TM1 | R => W | missense | 0.0001604 | 12 | 74808 | 0 | 0.0 | 0.999 | |
v2r_human | 66 | 1.61x61 | TM1 | G => S | missense | 1.245e-05 | 1 | 80292 | 0 | 0.07 | 0.444 | |
v2r_human | 67 | 1.62x62 | TM1 | R => W | missense | 1.235e-05 | 1 | 80987 | 0 | 0.0 | 0.959 | |
v2r_human | 68 | 1.63x63 | TM1 | R => Q | missense | 0.001164 | 93 | 79889 | 0 | 0.05 | 0.627 | |
v2r_human | 76 | 2.41x41 | TM2 | V => I | missense | 1.186e-05 | 1 | 84317 | 0 | 0.06 | 0.053 | |
v2r_human | 79 | 2.44x44 | TM2 | G => A | missense | 4.711e-05 | 4 | 84902 | 0 | 0.17 | 0.141 | |
v2r_human | 104 | 23.49x49 | ECL1 | R => H | missense | 9.27e-05 | 8 | 86304 | 0 | 0.01 | 1.0 | LB (polar (charge-assisted hydrogen bond)) |
v2r_human | 106 | 23.51x51 | ECL1 | R => H | missense | 0.0009726 | 84 | 86367 | 0 | 0.46 | 0.013 | |
v2r_human | 114 | 3.27x27 | TM3 | A => T | missense | 2.308e-05 | 2 | 86657 | 0 | 0.17 | 0.803 | |
v2r_human | 115 | 3.28x28 | TM3 | V => M | missense | 2.308e-05 | 2 | 86667 | 0 | 0.0 | 0.997 | |
v2r_human | 123 | 3.36x36 | TM3 | M => T | missense | 1.152e-05 | 1 | 86781 | 0 | 0.0 | 1.0 | LB (hydrophobic, Van der Waals) |
v2r_human | 128 | 3.41x41 | TM3 | Y => F | missense | 9.217e-05 | 8 | 86793 | 1 | 0.01 | 1.0 | |
v2r_human | 129 | 3.42x42 | TM3 | M => V | missense | 1.152e-05 | 1 | 86794 | 0 | 0.03 | 0.759 | |
v2r_human | 134 | 3.47x47 | TM3 | T => M | missense | 1.152e-05 | 1 | 86792 | 0 | 0.0 | 1.0 | |
v2r_human | 137 | 3.50x50 | TM3 | R => C | missense | 1.152e-05 | 1 | 86794 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
v2r_human | 139 | 3.52x52 | TM3 | R => H | missense | 0.0005875 | 51 | 86813 | 0 | 0.16 | 0.36 | |
v2r_human | 143 | 3.56x56 | TM3 | R => H | missense | 2.304e-05 | 2 | 86806 | 0 | 0.55 | 0.059 | GP (contact) |
v2r_human | 143 | 3.56x56 | TM3 | R => L | missense | 1.152e-05 | 1 | 86806 | 0 | 0.24 | 0.881 | GP (contact) |
v2r_human | 144 | 34.50x50 | ICL2 | P => A | missense | 2.304e-05 | 2 | 86820 | 0 | 0.0 | 1.0 | GP (contact) |
v2r_human | 147 | 34.53x53 | ICL2 | A => V | missense | 0.006035 | 524 | 86824 | 13 | 0.03 | 0.564 | GP (contact) |
v2r_human | 151 | 34.57x57 | ICL2 | G => R | missense | 1.152e-05 | 1 | 86818 | 0 | 0.08 | 0.949 | GP (contact) |
v2r_human | 153 | 4.39x39 | TM4 | G => E | missense | 6.912e-05 | 6 | 86810 | 0 | 0.69 | 0.864 | |
v2r_human | 158 | 4.44x44 | TM4 | R => Q | missense | 0.0001383 | 12 | 86758 | 0 | 0.29 | 0.06 | |
v2r_human | 159 | 4.45x45 | TM4 | P => S | missense | 1.153e-05 | 1 | 86737 | 0 | 0.02 | 0.732 | |
v2r_human | 162 | 4.48x48 | TM4 | V => A | missense | 6.941e-05 | 6 | 86443 | 0 | 0.37 | 0.023 | |
v2r_human | 163 | 4.49x49 | TM4 | A => S | missense | 2.315e-05 | 2 | 86407 | 0 | 0.07 | 0.994 | |
v2r_human | 170 | 4.56x56 | TM4 | L => V | missense | 1.162e-05 | 1 | 86092 | 0 | 0.03 | 0.904 | |
v2r_human | 199 | ECL2 | P => S | missense | 1.144e-05 | 1 | 87438 | 0 | 0.08 | 1.0 | ||
v2r_human | 202 | 5.35x36 | TM5 | R => C | missense | 1.143e-05 | 1 | 87488 | 0 | 0.02 | 0.735 | LB (polar (charge-assisted hydrogen bond)) |
v2r_human | 215 | 5.48x48 | TM5 | V => M | missense | 0.0004794 | 42 | 87617 | 1 | 0.0 | 0.981 | |
v2r_human | 223 | 5.56x56 | TM5 | A => T | missense | 0.0004907 | 43 | 87621 | 0 | 0.24 | 0.172 | |
v2r_human | 230 | 5.63x63 | TM5 | R => Q | missense | 4.566e-05 | 4 | 87606 | 0 | 0.01 | 0.989 | |
v2r_human | 233 | 5.66x66 | TM5 | H => R | missense | 1.141e-05 | 1 | 87615 | 0 | 0.13 | 0.988 | GP (contact) |
v2r_human | 244 | ICL3 | P => T | missense | 1.142e-05 | 1 | 87528 | 0 | 0.56 | 0.006 | ||
v2r_human | 245 | ICL3 | G => A | missense | 6.858e-05 | 6 | 87489 | 0 | 0.25 | 0.227 | ||
v2r_human | 247 | ICL3 | R => C | missense | 1.147e-05 | 1 | 87188 | 0 | 0.08 | 0.013 | ||
v2r_human | 247 | ICL3 | R => H | missense | 0.0008372 | 73 | 87199 | 0 | 0.14 | 0.022 | ||
v2r_human | 248 | ICL3 | R => C | missense | 9.175e-05 | 8 | 87191 | 0 | 0.05 | 0.048 | ||
v2r_human | 248 | ICL3 | R => H | missense | 4.588e-05 | 4 | 87187 | 0 | 0.15 | 0.048 | ||
v2r_human | 250 | ICL3 | G => E | missense | 0.000298 | 26 | 87242 | 0 | 0.11 | 0.069 | ||
v2r_human | 251 | ICL3 | R => G | missense | 0.0002981 | 26 | 87211 | 0 | 0.4 | 0.015 | ||
v2r_human | 251 | ICL3 | R => C | missense | 1.147e-05 | 1 | 87211 | 0 | 0.08 | 0.009 | ||
v2r_human | 251 | ICL3 | R => H | missense | 3.428e-05 | 3 | 87511 | 0 | 0.18 | 0.009 | ||
v2r_human | 252 | ICL3 | R => W | missense | 0.002446 | 214 | 87502 | 2 | 0.03 | 0.022 | ||
v2r_human | 252 | ICL3 | R => Q | missense | 4.572e-05 | 4 | 87493 | 0 | 0.31 | 0.041 | ||
v2r_human | 257 | ICL3 | G => S | missense | 4.569e-05 | 4 | 87537 | 0 | 1.0 | 0.002 | ||
v2r_human | 265 | 6.29x29 | TM6 | A => V | missense | 1.141e-05 | 1 | 87633 | 0 | 0.0 | 0.994 | GP (contact) |
v2r_human | 266 | 6.30x30 | TM6 | V => L | missense | 1.141e-05 | 1 | 87641 | 0 | 0.12 | 0.019 | SodiumPocket MicroSwitch |
v2r_human | 266 | 6.30x30 | TM6 | V => A | missense | 0.0001597 | 14 | 87638 | 0 | 0.03 | 0.297 | SodiumPocket MicroSwitch |
v2r_human | 268 | 6.32x32 | TM6 | K => R | missense | 1.141e-05 | 1 | 87654 | 0 | 0.05 | 0.999 | GP (contact) |
v2r_human | 270 | 6.34x34 | TM6 | V => G | missense | 1.141e-05 | 1 | 87656 | 0 | 0.0 | 0.943 | SodiumPocket MicroSwitch |
v2r_human | 270 | 6.34x34 | TM6 | V => A | missense | 1.141e-05 | 1 | 87656 | 0 | 0.03 | 0.381 | SodiumPocket MicroSwitch |
v2r_human | 279 | 6.43x43 | TM6 | V => I | missense | 4.565e-05 | 4 | 87628 | 0 | 0.12 | 0.786 | |
v2r_human | 295 | 6.59x59 | TM6 | A => S | missense | 1.16e-05 | 1 | 86211 | 0 | 0.01 | 0.955 | LB (Van der Waals, polar (hydrogen bond with backbone)) |
v2r_human | 295 | 6.59x59 | TM6 | A => V | missense | 1.161e-05 | 1 | 86106 | 0 | 0.83 | 0.035 | LB (Van der Waals, polar (hydrogen bond with backbone)) |
v2r_human | 298 | ECL3 | P => L | missense | 2.333e-05 | 2 | 85740 | 0 | 0.01 | 0.916 | ||
v2r_human | 300 | ECL3 | A => P | missense | 1.169e-05 | 1 | 85550 | 0 | 0.24 | 0.991 | ||
v2r_human | 305 | 7.33x32 | TM7 | A => T | missense | 0.0002373 | 20 | 84299 | 0 | 0.17 | 0.003 | |
v2r_human | 305 | 7.33x32 | TM7 | A => V | missense | 8.305e-05 | 7 | 84291 | 0 | 0.01 | 0.731 | |
v2r_human | 306 | 7.34x33 | TM7 | P => S | missense | 1.186e-05 | 1 | 84348 | 0 | 0.07 | 0.431 | |
v2r_human | 310 | 7.38x37 | TM7 | L => F | missense | 2.37e-05 | 2 | 84403 | 0 | 0.0 | 0.987 | |
v2r_human | 337 | 8.55x55 | H8 | R => Q | missense | 5.93e-05 | 5 | 84310 | 0 | nan | 0.961 | |
v2r_human | 340 | 8.58x58 | H8 | L => F | missense | 4.736e-05 | 4 | 84465 | 0 | 0.13 | 0.015 | |
v2r_human | 344 | 8.62x62 | H8 | R => G | missense | 2.358e-05 | 2 | 84829 | 0 | 0.26 | 0.024 | |
v2r_human | 344 | 8.62x62 | H8 | R => Q | missense | 5.885e-05 | 5 | 84959 | 0 | nan | 0.003 | |
v2r_human | 346 | C-term | R => C | missense | 4.7e-05 | 4 | 85107 | 0 | 0.01 | 0.003 | ||
v2r_human | 349 | C-term | P => L | missense | 1.167e-05 | 1 | 85661 | 0 | nan | 0.075 | ||
v2r_human | 352 | C-term | G => R | missense | 2.328e-05 | 2 | 85898 | 0 | nan | 0.897 | ||
v2r_human | 352 | C-term | G => D | missense | 0.0006866 | 59 | 85930 | 0 | 0.38 | 0.142 | ||
v2r_human | 357 | C-term | S => P | missense | 1.165e-05 | 1 | 85841 | 0 | 0.01 | 0.883 | ||
v2r_human | 357 | C-term | S => F | missense | 4.671e-05 | 4 | 85642 | 0 | 0.0 | 0.862 | ||
v2r_human | 359 | C-term | T => I | missense | 1.172e-05 | 1 | 85331 | 0 | nan | 0.862 | ||
v2r_human | 359 | C-term | T => N | missense | 1.172e-05 | 1 | 85331 | 0 | nan | 0.912 | ||
v2r_human | 368 | C-term | D => G | missense | 1.263e-05 | 1 | 79158 | 0 | 0.01 | 0.619 | ||
v2r_human | 371 | C-term | S => L | missense | 1.35e-05 | 1 | 74056 | 0 | nan | 0.336 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue